In the Blood (2006)

Trailer
Cassidy is a senior at a NYC college and he's trying to balance the demands of school, his role as big brother to Jessica, a freshman at the same school and his role as best buddy to horn-dog Mike with his emerging feelings of attraction to men. This is further complicated by a string of co-ed murders on campus for which his sister fits the victim profile. Topping off the mix are vivid dreams of Jessica covered in blood and Mike making a play for his sister.